Assistant Professor of Biological Engineering Research-at-a-glance: Angela received her B.
Angela Koehler. room C phone () email [email protected] Koehler Lab. phone () website. Administrative Assistant: Paul . Top Draw Results for July 15, Early Bird Draw. 02 04 05 06 Fine Art Phd Thesis,Angela Koller timberdesignmag.com about community service. We have a team of + writers, all English language native. While writing an essay for an English class may seem.
Inshe received her PhD in Chemistry from Harvard University where she worked with Professor Stuart Schreiber to develop novel technologies for identifying and characterizing interactions between proteins and small molecules.
The Koehler lab is focused on building chemical tools and methods for studying temporal aspects of transcriptional regulation in development and disease with a focus on cancer.
Transcription factors that become overactive in disease are promising yet untested targets for therapeutics. For example, these proteins mediate the excessive transcription of genes whose products are required for tumor growth and metastasis. Unlike enzymes, directly modulating the function of a transcription factor requires specific disruption or recruitment of DNA-protein or protein-protein interactions.
Our team is developing a general approach to small-molecule probe discovery for transcription factors by coupling direct binding assays with functional assays involving transcriptional and other phenotypic readouts.
The group also seeks to identify small-molecule probes of enzymes that regulate the acetylation status of these oncogenic transcription factors.
Several transcription factors are non-histone substrates of chromatin modifying enzymes.
The mechanistic consequences of acetylation status for transcription factors is not well understood but evidence suggests that these marks affect protein half-life and stable association with chromatin, among other functions.
The group uses a variety of biochemical and cellular approaches to identify compounds that serve as selective probes of function for specific HDACs or that selectively alter acetylation status of specific transcription factors in cells.
Specifically, the lab has an interest in identifying allosteric probes of functions distinct from enzymatic activities, such as protein-protein interactions involving cofactors or other members of the transcriptional machinery.Angela koller dissertation - Cooperate with our writers to get the excellent coursework meeting the requirements witness the benefits of qualified writing help available here top-ranked and affordable paper to make easier your education.
Angela received her B.A. in Biochemistry and Molecular Biology from Reed College in There she worked under the guidance of Professor Arthur Glasfeld on structural and biochemical studies of proteins that recognize tRNA or DNA. dissertation on self help group Angela Ehlers Dissertation creative writing essay layout phd thesis uwb antenna.
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